Friday, February 22, 2013

Facebook blocks NBC site after reported hack

Cnet Thursday 21st February, 2013

(Credit: Screenshot by Dan Terdiman) It seems Facebook is blocking links to NBC.com after the TV network's site was compromised earlier today. Some Facebook users trying to share URLs from NBC.com are running into an error message explaining that the feature isn't available at the moment. "An error occurred while processing this request. Please try again later," the message reads. The message pops up when posting from www.nbc.com. If you try to click on a link, another message pops up: "This link has been reported as abusive."

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Source: http://www.heraldglobe.com/index.php/sid/212745359/scat/d805653303cbbba8

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What Are Chinese Hackers Looking for in Cyber Attacks?

This transcript is automatically generated

To the Chinese and a stunning breadth of attacks you could darn near time do one every minute.

-- -- and -- corporation on many of the folks behind.

This unsettling bit of defense pressing news that has the white house on guard and curious media now on the attack.

-- first thought that China is denying being behind any of us how sure -- you that their line.

When there were very confident you know it's nice when you've got a lot of evidence you don't need to we're about a lot of hand waving in the propaganda that's being spewed.

I would -- right back to report the report re released yesterday.

Is extremely detailed -- we've been signs exclusive research we lay out.

A 141 different organizations that this group which we call a PT one or advanced persistent threat one is attacked.

-- weaving gets 3000 digital indicator signatures that we encourage other researchers to take and look at themselves so.

Despite China's you know yelling and it -- to the contrary your creditors didn't happen we just went right back -- the facts every time.

All right now we showed cases of attacks in general that have been in the news not all -- inspired or China led.

But enough up from decided that it leads me to this question how to -- Do you get in defense contractors computers because I would imagine.

They have a couple of more fire walls are a couple of better firewalls what happen.

He -- they -- make it look easy don't they the fact is it's actually not about fire -- have the best fire -- in the world.

But when it comes down to the weakest link in any organization -- a human being and that's that we see time and time again.

This group which we tied back to Chinese PL a unit 61398.

These guys are really masters not just a computer hacking but it social engineering the art of engineering human beings so you'll see them crap he's really.

Really elaborate very well thought out spear Phishing emails that look like they come from a pier and another organization or from your buddy that you know from the -- And the -- that he nobody you know opening attachments so you on the inside the organization are -- work for them.

All right so obviously warnings must go out to defense contractor workers that if you're getting in the email that appears to be coming from a colleague or -- source or friend or what have you.

You don't open -- at the very least -- that kinda freezes them and you know of the itself compromises.

Our defense and -- -- -- yet you can't be too careful with these kinds of things and what we we say again and again is no organization is immune to these kinds of tax because a bottom line is.

We all have human beings a worker organizations that are susceptible to -- -- this types of emails.

But I think the bigger key here is -- the open that email or not were up against a very determined very well financed well resource adversary.

So if you don't -- -- nearly gonna find another way and so they did they have great odds of -- of Maria just have already dead -- they jump in they get it let's say of Getty museum on working at.

General dynamics what have you and I I just respond do -- and now I'd given them access to.

My company right but what are getting what are they going through what are they combing.

So they're looking for specific intellectual property would -- they're tasked by the PLA so they're not just browsing around looking at pictures of the -- you had last fourth of July.

They're in there to find specific blueprints chemical formulas.

-- emails from executives talked about -- big acquisition you're about to do in Shanghai.

Becoming a specific tasking and -- given that toehold in the quickly pivot puts -- that's actually emailed back and forth.

Anyway with the defense establishments and isn't the better part of -- right in this crazy world.

That the -- other venues for which these high tech companies exchange information.

Sure it doesn't have to be in the Melvin Iraq -- open that email they can quickly pivot into your life if you file systems together in your computer but what's worse -- -- the entire organizations flat network and they can use to go anywhere they want to once again.

Scary stuff what do you think of their response that -- dog owning up have been edited it out they've been cut.

Caught -- but they're more -- saying we don't care.

-- they do -- I should say that we don't have a political dog in this fight we do this because that's what's led to do you know -- like to find in eradicate evil computer networks.

But you know that said we would would keep pointing back to the evidence its interest in China says these accusations are baseless -- professional.

We provide amount of evidence that points back to one particular neighborhood in Shanghai.

And it gets really answer the specific.

Allegations they feel that they don't have to that's right -- thank you.

That is tragic stuff you brits -- stuff all right.

Source: http://video.foxbusiness.com/v/2178907397001/what-are-chinese-hackers-looking-for-in-cyber-attacks/

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Thursday, February 21, 2013

Tehran's Azadi Tower, witness to history, victim of neglect

DUBAI (Reuters) - Within days of the 2009 election that returned President Mahmoud Ahmadinejad to office, demonstrations engulfed Tehran and other Iranian cities, centered on the capital's sprawling Azadi Square.

The unrest's defining moment took place on June 15 around the square's white marble monument, where photographer Hasan Sarbakhshian found himself in the early evening after walking street by street through western Tehran feeling a heady mix of hope, excitement and worry.

His press card revoked by authorities weeks earlier, Sarbakhshian used a simple digital camera to record the hundreds of thousands of people gathered in silence below the monument, accessory and observer to four decades of tumultuous political history.

"As a photographer I saw Azadi Tower as a character in my pictures," said Sarbakhshian, who also photographed pro-government rallies there and now lives in the United States. "It's a witness, a third eye."

But the tower, having stood through Iran's explosive revolution in 1979 and an eight-year-long war with Iraq in the 1980s, is now falling victim to neglect and shoddy repairs, and suffers from extensive internal water damage.

"Azadi Tower is exposed to humidity, and still no one has paid any attention," Seyyed Mohammad Beheshti, an architect and former cultural heritage official, told the Iranian Students' News Agency (ISNA) recently. "The past disregard of this valuable building must be rectified."

Completed in 1971, the tower is shaped in the form of an inverted letter Y and features a design influenced by both pre- and post-Islamic architecture.

Iranian news organizations have published pictures of cracked stones, water dripping from ceilings and peeling walls. ISNA quoted an unnamed expert as saying repairs in 2010 to the tower and the museum complex below were to blame.

"Two years ago the municipality rebuilt (Azadi), and drainage systems in different sections of the complex were destroyed," the expert told ISNA in December. "Now, with the slightest rain, the rainwater has nowhere to go."

A committee has been formed to determine next steps, but any repairs must be delayed until the weather warms up.

"Azadi Tower's foundations and ceiling are stricken with serious problems," municipal official Gholamreza Ahmadi told state news agency IRNA.

"Azadi Tower has not been well cared for."

A SIMPLE YOUNG BOY

News of the damage to a structure that has served as a symbol of Tehran to the outside world concerns many Iranians, not least the monument's creator, Hossein Amanat.

A member of the persecuted Baha'i faith, Amanat was one of many prominent Iranians compelled to leave the country during the 1979 Islamic Revolution. He is worried that the authorities will not address the problem urgently or competently.

"I feel responsible to talk about how urgent it is for them ... to correct the damage they have done themselves to this building," he said in a telephone interview. "They should find qualified and informed people to do it."

Amanat was 24 when he spotted a two-paragraph notice in the Etelaat newspaper in 1966 advertising a contest to design a monument to commemorate 2,500 years of Persian monarchy.

A fresh graduate of the University of Tehran's architecture school, he had planned to emigrate to the United States to continue his studies but stayed instead to work on his design.

The resulting monument features two prominent arches: one a sweeping parabola reminiscent of ancient Iranian architecture, and the other more representative of Iran's Islamic identity, evoking its many grand mosques.

"It's really an allusion to prominent periods in the history of Iran," said Amanat, now 70 and living in Canada. "It reflects my great imaginations about the history of Iran and the fascination it had for me since childhood.

"It is the essence that I understood as a simple young boy in those days."

GATEWAY TO TEHRAN

The completed tower was named Shahyad Aryamehr, or King Memorial, and coincided with a push by the Shah Mohammad Reza Pahlavi to encourage tourism and investment by the West. Its shape, suggesting a curtain fluttering open in the wind, was an entrance to the city.

"Shahyad became the perfect metaphor for the many cultural paradoxes that were the rapidly changing Tehran," wrote Abbas Milani, an Iran expert at Stanford University, in his 2011 biography of the Shah. "Shahyad was a gateway to the future and a celebration of the past."

But by the late 1970s, the monarchy that Shahyad was built to honor was losing its grip on power. Iranians flocked to Shahyad Square during the revolution to demand the return of exiled Ayatollah Ruhollah Khomeini, who would eventually found the Islamic Republic.

Grainy photos show them bearing banners with Khomeini's picture and standing atop the gleaming monument's base.

Those images helped the tower shed its royal associations and ensure its survival under Iran's new rulers, who removed other icons connected to the Shah but embraced Shahyad, renaming it Azadi, or Freedom.

The square is now often used for pro-government rallies, including to mark the 34th anniversary of the Islamic revolution on February 10.

"This monument is not owned by me or anybody," Amanat said. "It is something that people in Iran have some connection to."

Previous repairs to the tower used cheap substitutes in place of the original high-quality materials, ISNA has reported, raising doubts about whether future repairs, when they occur, could restore the tower to its former glory.

"Not many people know the intricacies in the building," Amanat said. "It's a very simple building, but it is very delicate."

He said he sees the damage to Azadi as symbolic of the country's struggles. In recent weeks, top officials have traded public accusations of corruption, and Western sanctions over Iran's nuclear program have weighed heavily on the economy and eroded the value of its currency.

"It reflects how the country is being managed," Amanat said. "It's still standing, but it's not the way it should be."

(Editing by Marcus George and Sonya Hepinstall)

Source: http://news.yahoo.com/tehrans-azadi-tower-witness-history-victim-neglect-141219013.html

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Japan's new government embraces death penalty viah three new executions

? George Will makes strong (conservative?) case against solitary confinement | Main

February 21, 2013

Japan's new government embraces death penalty viah three new executions

As reported in this new piece from The Guardian, headlined " Japan executions resume with three hangings: Hopes dashed of reprieve under Shinzo Abe's government with first sentences carried out since September 2012," Japan new government carried out its first set of executions this week.? Here are details on the latest executions and concerning Japan's recent capital punishment history:

Japan has carried out three executions -- the first since the country's conservative prime minister, Shinzo Abe, was elected last December, and a sign that Tokyo will defy international pressure to abolish the death penalty.

The justice ministry said the executions were carried out in the early hours of Thursday in three different locations.? One of the condemned men, Kaoru Kobayashi, had been sentenced to death for the abduction, sexual assault and murder of a seven-year-old schoolgirl in 2004.? He sent a photograph of the murdered girl to her mother.

The executions, the first since September 2012, could signal a return to more regular hangings under the current justice minister, Sadakazu Tanigaki.? "I ordered the executions after giving them careful consideration," Tanigaki told reporters.? "These were extremely cruel cases in which the victims had their precious lives taken away for very selfish reasons."

Amnesty International Japan condemned the executions. "The Japanese government cannot be excused from abiding by international human rights standards, just by citing opinion among the public," it said in a statement.? Opinion polls put support for capital punishment among the Japanese at about 80%.

Earlier this year Tanigaki indicated he would have no hesitation in signing execution orders; some previous holders of the post had refused to approve them, leading to a de facto moratorium.? "I will have to do what needs to be done according to the rule of law," he told journalists, adding that the secrecy surrounding hangings would continue.? Inmates are given very little notice before they are led to the gallows and their families are informed only after the executions have taken place.? "Even death row inmates have guarantees of privacy and we have to consider the feelings of their relatives," Tanigaki said. "I don't think it is necessarily a good idea to release more information."

At the end of last year Japan had 133 inmates on death row, the highest number since records were first kept in 1949.? They include Shoko Asahara, leader of the doomsday cult behind the 1995 sarin gas attacks on the Tokyo subway in which 13 people died and thousands were made ill.

The previous government, led by the left-of centre Democratic party of Japan (DPJ), executed nine people during its three years and three months in office.? That included an 18-month period from July 2010 in which no hangings took place.? In the three years to 2008 there were 28 executions under LDP administrations.

The DPJ raised hopes among abolitionists in 2010 when it established a panel to look into Japan's use of capital punishment but the body was disbanded without reaching a conclusion in January 2012.

February 21, 2013 at 05:41 PM | Permalink

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Gunshot, screams, then more shots at Pistorius home: police

LOS ANGELES (Reuters) - The teenage son of late pop star Michael Jackson has signed up to be a correspondent for the "Entertainment Tonight" television show, following in the footsteps of his show business family. Prince Jackson, 16, was to debut on "Entertainment Tonight" on Tuesday, interviewing actors James Franco, Zach Braff and director Sam Raimi as they promote their upcoming film "Oz the Great and Powerful," the program said. Prince, who was born Michael Joseph Jackson Jr., is the oldest of Michael Jackson's three children. ...

Source: http://news.yahoo.com/gunshot-screams-then-more-shots-pistorius-home-police-100936628--spt.html

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Wednesday, February 20, 2013

Genome-wide imaging study identifies new gene associated with Alzheimer's plaques

Feb. 20, 2013 ? A study combining genetic data with brain imaging, designed to identify genes associated with the amyloid plaque deposits found in Alzheimer's disease patients, has not only identified the APOE gene -- long associated with development of Alzheimer's -- but has uncovered an association with a second gene, called BCHE.

A national research team, led by scientists at the Indiana University School of Medicine, reported the results of the study in an article in Molecular Psychiatry posted online February 19. The study is believed to be the first genome-wide association study of plaque deposits using a specialized PET scan tracer that binds to amyloid.

The research also is believed to be the first to implicate variations in the BCHE gene in plaque deposits visualized in living individuals who have been diagnosed with Alzheimer's disease or are at-risk for developing the disease. The enzyme coded by the BCHE gene has previously been studied in post-mortem brain tissue and is known to be found in plaques.

"The findings could recharge research efforts studying the molecular pathways contributing to amyloid deposits in the brain as Alzheimer's disease develops and affects learning and memory," said Vijay K. Ramanan, the paper's first author and an M.D./Ph.D. student at the IU School of Medicine.

The BCHE gene finding "brings together two of the major hypotheses about the development of Alzheimer's disease," said Andrew J. Saykin, Psy.D., Raymond C. Beeler Professor of Radiology and Imaging Sciences at IU and principal investigator for the genetics core of the Alzheimer's Disease Neuroimaging Initiative.

Scientists have long pointed to the loss of an important brain neurotransmitter, acetylcholine, which is depleted early in the development of the disease, as a key aspect of the loss of memory related neurons. The BCHE gene is responsible for an enzyme that breaks down acetylcholine in the brain. The other major Alzheimer's hypothesis holds that the development of the amyloid plaques is the primary cause of the disease's debilitating symptoms. As it turns out, the enzyme for which the BCHE gene codes is also found in significant quantities in those plaques.

"This study is connecting two of the biggest Alzheimer's dots," said Dr. Saykin, director of the Indiana Alzheimer Disease Center and the IU Center for Neuroimaging at the IU Health Neuroscience Center.

"The finding that BCHE gene variant predicts the extent of plaque deposit in PET scans among people at risk for Alzheimer's disease is likely to reinvigorate research into drugs that could modify the disease by affecting the BCHE enzyme or its metabolic pathway," he said. Some existing drugs inhibit this enzyme, but it is unclear whether this influences plaque deposits.

Overall, the results appear to offer scientists new potential targets for drugs to slow, reverse or even prevent the disease. Alzheimer's disease affects an estimated 5.4 million Americans and has proven resistant to treatments that do more than temporarily slow the worsening of symptoms.

Amyloid plaque deposits build up abnormally in the brains of Alzheimer's patients and are believed to play an important role in the memory loss and other problems that plague patients.

The study makes use of an imaging agent, florbetapir, now approved for use by the U.S. Food and Drug Administration, that allows physicians to see the level of plaque buildup in a patient's brain, something that previously could be determined only with an autopsy.

In a genome-wide association study, researchers evaluate alternate versions of many genes to determine whether particular genetic variants are associated with a particular trait -- in this case, the amounts of amyloid plaque deposits that the PET scans revealed in the brains of study participants.

Using the imaging agent that enables detection of the plaques in the brain, the researchers conducted PET scans of 555 participants in the Alzheimer's Disease Neuroimaging Initiative, a long-term public-private research project that includes people at risk for Alzheimer's disease and patients who have been diagnosed with the disease as well as participants with no symptoms.

With sophisticated statistical analyses, the imaging data was combined with analyses of DNA collected from the 555 participants to determine whether particular gene variants were found more often among patients with higher levels of plaque deposits.

The analysis found that a variant in BCHE was significantly associated with the levels of plaque deposits. As would be expected, the analysis also found a strong association with variants of another gene, APOE, that has long been known to be associated with the development of Alzheimer's. The effect of BCHE was independent of APOE, however. Moreover, the effects of the two genes were additive -- that is, people with the suspect variants of both genes had more plaque deposits than people who had only one of the variants associated with plaque development.

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The above story is reprinted from materials provided by Indiana University.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. V K Ramanan, S L Risacher, K Nho, S Kim, S Swaminathan, L Shen, T M Foroud, H Hakonarson, M J Huentelman, P S Aisen, R C Petersen, R C Green, C R Jack, R A Koeppe, W J Jagust, M W Weiner, A J Saykin. APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study. Molecular Psychiatry, 2013; DOI: 10.1038/mp.2013.19

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/lcMKpbKxQM4/130220153701.htm

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Novel coronavirus well-adapted to humans, susceptible to immunotherapy

Tuesday, February 19, 2013

The new coronavirus that has emerged in the Middle East is well-adapted to infecting humans but could potentially be treated with immunotherapy, according to a study to be published on February 19 in mBio?, the online open-access journal of the American Society for Microbiology. The study indicates that the virus HCoV-EMC can penetrate the lining of the passageways in the lung and evade the innate immune system as easily as a cold virus can, signs that HCoV-EMC is well-equipped for infecting human cells. The study also reveals that the virus is susceptible to treatment with interferons, components of the immune system that have been used successfully to treat other viral diseases, opening a possible mode of treatment in the event of a large-scale outbreak.

"Surprisingly, this coronavirus grows very efficiently on human epithelial cells," says co-author Volker Thiel of The Institute of Immunobiology at Kantonal Hospital in St. Gallen, Switzerland. Thiel says these new data indicate that although HCoV-EMC may have jumped from animals to humans very recently, it is just as well adapted to infecting the human respiratory tract as other, more familiar human coronaviruses, including the SARS virus and the common cold virus, HCoV-229E.

HCoV-EMC first came to light in June when it was isolated from a man in Saudi Arabia who died from a severe respiratory infection and kidney failure. Since that time, public health officials have identified an additional 10 infected persons, nine of whom had traveled in the Middle East and one who had recent contact with an infected person. The emergence of HCoV-EMC, which is related to the SARS virus, has raised concern that it may eventually lead to a pandemic much like the SARS pandemic of 2002-2003, which is estimated to have sickened over 8,000 people and killed 774 worldwide.

For the mBio? study, Thiel and his colleagues tested how well HCoV-EMC could infect and multiply in the entryways to the human lung using cultured bronchial cells manipulated to mimic the airway lining. The lining of the lung, or epithelium, represents an important first barrier against respiratory viruses, but they apparently don't put up a big fight against HCoV-EMC, says Thiel. He and his colleagues found that human airway epithelial cells are highly susceptible to HCoV-EMC infection and that the virus is able to multiply at a faster initial rate than the SARS virus.

"The other thing we found is that the viruses [HCoV-EMC, SARS, and the common cold virus] are all similar in terms of host responses: they don't provoke a huge innate immune response," Thiel says. This is an indication that HCoV-EMC is already well adapted to the human host and that the virus uses that same strategy other coronaviruses use for evading the host's non-specific immune mechanisms.

The authors asked themselves whether boosting this weak immune response might diminish the virus' ability to infect airway epithelial cells. They found that pre-treating the cells with lambda-type interferons, proteins that are released by host cells in response to infection and enable communication between cells to mount an immune response, significantly reduced the number of infected cells. This is encouraging from a treatment standpoint, note the authors, since interferons have also shown a good deal of promise for treating SARS and another viral illness, Hepatitis C.

Thiel and co-author Ronald Dijkman emphasize that their work with HCoV-EMC would not have been possible without the efforts of many different research groups from Switzerland, Germany, The Netherlands, and Denmark.

Ongoing collaboration is crucial, they say. Future research to head off outbreaks of HCoV-EMC and other emerging diseases requires cooperation and trust among scientists and health agencies, a goal that is not always achieved. The future of this virus is uncertain, Thiel points out, but access to samples from a wider range of patients and epidemiological work could answer some fundamental questions, including where the virus is coming from and what the true prevalence of the virus is.

"We don't know whether the cases we observe are the tip of the iceberg," says Thiel. "Or whether many more people are infected without showing severe symptoms."

###

American Society for Microbiology: http://www.asm.org

Thanks to American Society for Microbiology for this article.

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Source: http://www.labspaces.net/126873/Novel_coronavirus_well_adapted_to_humans__susceptible_to_immunotherapy

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